Anti-Human CD354 MAb (Clone: 6B1)
Product Sizes
0.1 mg
£541.00
30-2855-0.1MG
About this Product
- SKU:
- 30-2855
- Additional Names:
- TREM1
- translate.label.attr.clone:
- 6B1
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: The mouse monoclonal antibody 6B1 (also known as 6B1.1G12) recognizes an extracellular epitope of human CD354 (TREM-1); a transmembrane glycoprotein; serving as an important innate immunity receptor. CD354 (TREM-1); a cell surface glycoprotein expressed mainly on monocytes; macrophages; and neutrophils; but also on e.g. endothelial cells or bronchial epithelium; plays an important role in innate immune responses. Upon triggering by its ligands (mainly bacterial and fungal components; but also some viruses; such as Marburg or Ebola virus); it initiates signaling cascades leading to release of pro-inflammatory cytokines and chemokines. CD354 is strongly present in infectious inflammatory lesions (e.g. in folliculitis or impetigo); but not so much in non-infectious inflammatory lesions; (e.g. vasculitis or psoriasis). However; under certain conditions neutrophils can upregulate CD354 also under non-infectious inflammatory conditions; e.g. in rheumatoid arthritis. Soluble CD354 (sTREM-1) is an important biomarker for identification of septic patients; as well as for prediction of their survival.
- Host:
- Mouse
- Immunogen:
- recombinant human CD354 fused with IgG
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze. Phosphate buffered saline (PBS); pH 7.4; 15 mM sodium azide
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
