Anti-SCIMP PE MAb (Clone: NVL-07)
Product Sizes
100 tests
£738.00
30-2854-100TESTS
About this Product
- SKU:
- 30-2854
- Additional Names:
- NVL
- translate.label.attr.clone:
- NVL-07
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- Specificity: The mouse monoclonal antibody NVL-07 recognizes intracellular part of human transmembrane adaptor SCIMP. This protein of 17 kDa predicted Mw migrates as a 22 kDa band on SDS PAGE. SCIMP (SLP adaptor and Csk interacting membrane protein); also known as Nvl; is a palmitoylated transmembrane adaptor protein expressed in professional antigen presenting cells; most prominently in the lymph nodes and spleen. It is associated with tetraspanin-enriched microdomains (together with MHC II). There is a close relationship between SCIMP and tyrosinkinase Lyn; which is constitutively bound to it by its SH3 domain. After MHC II-mediated stimulation in the immunological synapse SCIMP becomes phosphorylated at several tyrosine residues and provides docking sites for Grb2 and SLP65 or SLP76 adaptors transducing the signal downstream; as well as for the kinase Csk with modulatory roles.
- Host:
- Mouse
- Immunogen:
- Recombinant intracellular part of human SCIMP
- Isotype:
- Mouse IgG2a
- Purification:
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:30-2854.jpg
