Anti-Human CD100 FITC MAb (Clone: 133-1C6)
Product Sizes
100 tests
£581.00
30-2849-100TESTS
About this Product
- SKU:
- 30-2849
- Additional Names:
- COLL4; SEMA4D; semaphorin 4D
- translate.label.attr.clone:
- 133-1C6
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- Specificity: The mouse monoclonal antibody 133-1C6 recognizes an extracellular epitope of CD100; an approximately 150 kDa (when reduced) semaphorin family member expressed mainly on lymphocytes; NK cells; monocytes/macrophages and granulocytes; but also on some non-hematopoietic cells. CD100; also known as semaphorin 4D; is a homodimerizing type I transmembrane glycoprotein containing an extracellular semaphorin domain. It is expressed on most hematopoietic cells with the exception of immature bone marrow cells; erythrocytes and platelets. A 120 kDa soluble form is generated from the transmembrane form by proteolytic cascade following primary T and B cell activation. It seems CD100 acts through dampening CD72-mediated negative signaling. CD100 promotes angiogenesis; invasive growth; proliferation and anti-apoptosis of cancer cells in vitro. Higher expression levels of CD100 correlate with poor survival in soft tissue sarcoma patients.
- Host:
- Mouse
- Immunogen:
- PHA stimulated human PBL
- Isotype:
- Mouse IgM
- Purification:
- Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
