Anti-Cyclin D1 Biotin MAb (Clone: DCS-6)
Product Sizes
0.1 mg
£581.00
30-2838-0.1MG
About this Product
- SKU:
- 30-2838
- Additional Names:
- CYC-D1; CCND1; BCL1; PRAD1; U21B31
- translate.label.attr.clone:
- DCS-6
- Clonality:
- Monoclonal
- Conjugate:
- Biotin
- Extra Details:
- Specificity: The mouse monoclonal antibody DCS-6 recognizes cyclin D1; an ubiquitously expressed 33 kDa protein that migrates as a 36 kDa band under reducing SDS-PAGE conditions. Cyclin D1 (PRAD1; Bcl-1) is a cytoplasmic and nuclear protein; which is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation; and titrate CDK inhibitors such as p21Cip1 and p27Kip1. Whereas during G1 phase cyclin D1 accumulates in the nucleus; it translocates into the cytoplasm during S phase. Without growth factor-mediated stimulation cyclin D1 is unstable; and undergoes ubiquitin-mediated degradation; which is triggered by its phosphorylation. Cyclin D1 destabilization participates in G1/S phase arrest.
- Host:
- Mouse
- Immunogen:
- Recombinant human cyclin D1 (amino acids 1-295)
- Isotype:
- Mouse IgG2a
- Purification:
- Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
