Anti-Human IL-17A MAb (Clone: 9F9)
Product Sizes
0.1 mg
£562.00
30-2837-0.1MG
About this Product
- SKU:
- 30-2837
- Additional Names:
- Interleukin 17; Interleukin 17A; IL17A; Anti-Hu IL-17A Purified
- translate.label.attr.clone:
- 9F9
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: The mouse monoclonal antibody 9F9 recognizes human interleukin 17A (IL-17A; secreted or intracellular). Interleukin 17A (IL-17A) is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules; chemokines; antimicrobial peptides; and remodeling proteins. It plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. It is the signature effector cytokine of Th17 cells; and in this role it primarily induces neutrophil activation and recruitment at infection and inflammatory sites. High levels of IL-17A are associated with rheumatoid arthritis; psoriasis; multiple sclerosis; and another inflammatory diseases; including lung injugy during severe COVID 19. This cytokine also contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13; enhancing retention of B cells within the germinal centers; B cell somatic hypermutation rate and selection toward plasma cells. It is an effector cytokine for invariant NKT cells (iNKT); and it is involved in epithelial barrier formation upon injury.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Mammalian-derived human IL-17-IgG fusion protein; boost with recombinant human IL-17A
- Isotype:
- Mouse IgG1 kappa
- Purification:
- Purified by protein-A affinity chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
