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Antibodies

Anti-Hu CD118 (Clone: 12D3) Purified

Product Sizes
0.1 mg
£541.00
30-2833-0.1MG
About this Product
SKU:
30-2833
Additional Names:
LIF receptor subunit alpha LIFR alpha; SWS; SJS2; STWSm; gp190
translate.label.attr.clone:
12D3
Clonality:
Monoclonal
Extra Details:
CD118 (LIFR alpha) is a type I transmembrane glycoprotein of the cytokine receptor family; which associates noncovalently with CD130 to form the functional high affinity LIF receptor; which also acts as an oncostatin M receptor. CD118 alone binds LIF with low affinity. A secreted form of CD118 results from alternative splicing; and may have inhibitory effect; as it also binds LIF; although with low affinity. CD118 is not expressed on lymphocytes; but it is widely expressed outside the immune system. Soluble CD118 level rises during pregnancy; in parallel with a drop in circulating LIF levels. Specificity :The mouse monoclonal antibody 12D3 recognizes an extracellular epitope of CD118; a transmembrane glycoprotein; which associates with CD130 to form the functional high affinity LIF receptor.
Format:
Purified
Immunogen:
human recombinant soluble CD118-Fc
Isotype:
Mouse IgG1 kappa
Purification:
Purified by protein-A affinity chromatography.
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at 2-8[o]C. Do not freeze.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
Figure 1: Separation of JAR cells stained using anti-human CD118 (12D3) purified antibody (GAM APC; red-filled) from JAR cells unstained by primary antibody (GAM APC; black-dashed) in flow cytometry analysis (surface staining) of JAR cell suspension.