Anti-Hu CD33 Purified
Product Sizes
0.1 mg
£532.00
30-2789-0.1MG
About this Product
- SKU:
- 30-2789
- Additional Names:
- CD33 molecule SIGLEC3; p67
- translate.label.attr.clone:
- WM53
- Clonality:
- Monoclonal
- Extra Details:
- CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage; binds sialic acid residues in N- and O-glycans on cell surfaces; and is a therapeutic target for acute myeloid leukemia.Specificity :The mouse monoclonal antibody WM53 reacts with an extracellular epitope of CD33; a 67 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed on myeloid progenitors; monocytes; granulocytes; dendritic cells and mast cells; it is absent on platelets; lymphocytes; erythrocytes and hematopoietic stem cells.
- Format:
- Purified
- Immunogen:
- Human AML cells
- Purification:
- Purified by protein-A affinity chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
