APC Conjugated Anti-Hu CD370 Antibody (Clone:8F9)
Product Sizes
100 Tests
£649.00
30-2784AC-100TESTS
About this Product
- SKU:
- 30-2784AC
- Additional Names:
- C-type lectin domain containing 9A CLEC9A; DNGR1; DNGR-1; UNQ9341
- translate.label.attr.clone:
- 8F9
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- CD370 / CLEC9A; also known as DNGR1; is a type II transmembrane glycoprotein with extracellular C-type lectin domain and intracellular ITAM-containing domain. Its expression is restricted to BDCA3+ conventional dendritic cells and to a subset of CD14+ CD16- monocytes. CD370 serves as a receptor for ubiquitous preformed acid-labile protein associated ligands that are exposed when the cell membrane is damaged; such as on necrotic cells. Its triggering by these ligands mediates recruitment and activation of the tyrosine kinase Syk and leads to their cross-presentation to the immune system. Specificity :The mouse monoclonal antibody 8F9 recognizes an extracellular epitope of CD370 / CLEC9A (DNGR1); a type II transmembrane protein functioning as an endocytic receptor on BDCA31+ dendritic cells and on a subset of CD14+ CD16- monocytes.
- Immunogen:
- RBL-2H3 cells expressing human CLEC9A fused to an HA epitope
- Purification:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies
- Manufacturer's Data Sheet:download_pdf.php
