Anti-Hu CD45 Biotin
Product Sizes
0.1 mg
£581.00
30-2775-B-0.1MG
About this Product
- SKU:
- 30-2775-B
- Additional Names:
- protein tyrosine phosphatase receptor type C LCA; T200; LY5; B220; GP180; TPC
- translate.label.attr.clone:
- 2D1
- Clonality:
- Monoclonal
- Conjugate:
- Biotin
- Extra Details:
- Specificity: The mouse monoclonal antibody 2D1 reacts with an extracellular epitope of all alternative forms of human CD45 antigen (Leukocyte Common Antigen); a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin; except from erythrocytes and platelets. Description: CD45 (LCA; leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells; comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling; serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains; whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling; CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. Specificity :The mouse monoclonal antibody 2D1 reacts with an extracellular epitope of all alternative forms of human CD45 antigen (Leukocyte Common Antigen); a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin; except from erythrocytes and platelets.
- Immunogen:
- Human peripheral blood mononuclear cells
- Isotype:
- Mouse IgG1 kappa
- Purification:
- Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:img1.jpg
