Anti-Hu CD79a (Clone ZL7.4) APC
Product Sizes
100 Tests
£620.00
30-2757-100TESTS
About this Product
- SKU:
- 30-2757
- Additional Names:
- CD79a molecule BCR alpha; Ig-alpha; MB-1; IGA
- translate.label.attr.clone:
- ZL7.4
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- CD79a (Ig alpha; MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs); and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently; in pre-B cells; CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage; CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn; which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. Specificity :The mouse monoclonal antibody ZL7.4 interacts with extracellular domain of CD79a (Ig alpha); a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.
- Immunogen:
- IgM complex isolated from Daudi cells
- Purification:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:30-2757.jpg
