Anti-Hu CD79b Purified
Product Sizes
0.1 mg
£532.00
30-2754-0.1MG
About this Product
- SKU:
- 30-2754
- Additional Names:
- CD79b molecule BCR beta; Ig-beta; B29; IGB
- translate.label.attr.clone:
- CB3-1
- Clonality:
- Monoclonal
- Extra Details:
- CD79b (Ig beta; B29) forms disulfide-linked heterodimer with CD79a (Ig alpha; MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs); and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently; in pre-B cells; CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn; which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.Specificity :The mouse monoclonal antibody CB3-1 recognizes an extracellular epitope of CD79b (CD79 beta; Ig beta); an approximately 38 kDa component of B cell receptor (BCR) complex.
- Format:
- Purified
- Immunogen:
- Fraction of Ig-associated molecules isolated from Ramos B cells
- Purification:
- Purified by protein-A affinity chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
