Anti-p53 Purified
Product Sizes
0.1 mg
£541.00
30-2725-0.1MG
About this Product
- SKU:
- 30-2725
- Additional Names:
- tumor protein p53 BCC7; TRP53; TP53; LFS1
- translate.label.attr.clone:
- BP53-12
- Clonality:
- Monoclonal
- Extra Details:
- The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes; resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest; or proteins that trigger apoptosis; such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain; central DNA-binding domain; oligomerisation domain; and C-terminal regulatory domain. There are various phosphorylation sites on p53; of which the phosphorylation at Ser15 is important for p53 activation and stabilization. Specificity :The antibody BP53-12 recognizes a defined epitope (aa 16-25) on human p53; a 50 kDa intracellular tumour suppressor found in increased amounts in a wide variety of transformed cells; it is frequently mutated or inactivated in many types of cancer.
- Format:
- Purified
- Immunogen:
- Bacterially expressed full-length wild-type p53
- Purification:
- Purified by sequential steps of physicochemical fractionation (differential precipitation and solid-phase chromatography methods).
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
