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Antibodies

Anti-PPM1D Purified

Product Sizes
0.1 mg
£541.00
30-2720-0.1MG
About this Product
SKU:
30-2720
Additional Names:
protein phosphatase; Mg2+/Mn2+ dependent 1D WIP1; Protein phosphatase 1D; JDVS; WIP1; IDDGIP
translate.label.attr.clone:
7E11/C5
Clonality:
Monoclonal
Extra Details:
PPM1D is a Mg2+/Mn2+ dependent protein phosphatase 1D with inducible expression in response to various types of environmental stress. This expression is p53-dependent; and subsequently PPM1D negatively regulates the p53-mediated transcription; thus it suppresses the apoptosis. PPM1D contributes to development of carcinomas; and seems to be a promissing therapeutic target. Amplification of PPM1D is associated with breast cancer. Specificity :The mouse monoclonal antibody 7E11/C5 recognizes an epitope within the sequence FTNEDELYNLLTDSP of PPM1D; a protein phosphatase; which contributes to development of some carcinomas.
Format:
Purified
Immunogen:
Purified human PPM1D
Purification:
Purified by protein-A affinity chromatography.
Reactivities:
Mouse
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at 2-8[o]C. Do not freeze.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
Figure 1: Western blotting analysis of human PPM1D using mouse monoclonal antibody 7E11/C5 on lysates of U2OS parental cells; expressing both natural (70 kDa; low expression) and C-terminally truncated version (55 kDa; high expression) of PPM1D; and on lysates of MCF7 cells (high PPM1D expression) and RPE cells (low PPM1D expression); reducing conditions.