Anti-TIAR Purified
Product Sizes
0.1 mg
£541.00
30-2710-0.1MG
About this Product
- SKU:
- 30-2710
- Additional Names:
- TIA1 cytotoxic granule associated RNA binding prot TCBP; TIAL1
- translate.label.attr.clone:
- 6E3
- Clonality:
- Monoclonal
- Extra Details:
- TIAR is an ubiquitously expressed RNA-binding protein; which regulates translational control; splicing; and other activities; including apoptosis. TIAR attenuates CDK1 activity; and is essential for the G2/M checkpoint. It accumulates in nuclear foci in late G2 phase and prophase in cells under replication stress. In steady state TIAR shuttles between the cytoplasm and the nucleus; probably as a part of nucleocytoplasmic transport of mRNA; but under stress conditions it accumulates mRNA molecules in granules and prevents their translation. Nucleolytic activity of TIAR against attacked target cells of cytotoxic lymphocytes has also been reported. Similarly; e.g. in permeabilized thymocytes TIAR triggers DNA fragmentation. Specificity :The mouse monoclonal antibody 6E3 recognizes TIAR; an ubiquitously expressed approximately 42 kDa intracellular RNA-binding protein.
- Format:
- Purified
- Immunogen:
- GST-tagged recombinant human TIAR
- Purification:
- Purified by protein-A affinity chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:30-2710.jpg
