Anti-Human CD268 APC (Clone : 11C1)
Product Sizes
100 tests
£620.00
30-2604-100TESTS
About this Product
- SKU:
- 30-2604
- Additional Names:
- TNFRSF13C; BAFFR; CVID4; BAFF-R; BROMIX; prolixin;TNF receptor superfamily member 13C
- translate.label.attr.clone:
- 11C1
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- CD268 / BAFF R is a TNFR family receptor that binds the B-cell-activating factor (CD257 / BAFF). Splice variants of CD268 have been observed both in man and mouse. A naturally occurring mutation of CD268 in A/WySnJ mice is associated with low number of mature B cells; but with normal B cell precursors. The role of BAFF in B-cell survival and activation make CD268 a potential diagnostic reagent. It may be involved in survival of B-cell malignancies. Experimental administration of a CD268-Fc fusion protein suppresses antibody responses. In T cells the CD268 costimulates their activation and proliferation. Defects in CD268 cause the common variable immunodeficiency 4 (CVID4).Specificity : The mouse monoclonal antibody 11C1 recognizes an extracellular epitope of CD268 / BAFF R (B cell-activating factor receptor); a 19 kDa type III transmembrane protein expressed on resting B cells and CD4-positive T cells; but down regulated after activation.
- Immunogen:
- human CD268-transfected murine L1.2 cells
- Isotype:
- Mouse IgG1 kappa
- Purification:
- The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
