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Antibodies

PE Conjugated Anti-CD370 Antibody (Clone : 8F9)

Product Sizes
100 tests
£649.00
30-2570PE-100TESTS
About this Product
SKU:
30-2570PE
Additional Names:
CLEC9A; DNGR1; DNGR-1; UNQ9341;C-type lectin domain containing 9A
translate.label.attr.clone:
8F9
Clonality:
Monoclonal
Conjugate:
PE
Extra Details:
CD370 / CLEC9A; also known as DNGR1; is a type II transmembrane glycoprotein with extracellular C-type lectin domain and intracellular ITAM-containing domain. Its expression is restricted to BDCA3+ conventional dendritic cells and to a subset of CD14+ CD16- monocytes. CD370 serves as a receptor for ubiquitous preformed acid-labile protein associated ligands that are exposed when the cell membrane is damaged; such as on necrotic cells. Its triggering by these ligands mediates recruitment and activation of the tyrosine kinase Syk and leads to their cross-presentation to the immune system. Specificity : The mouse monoclonal antibody 8F9 recognizes an extracellular epitope of CD370 / CLEC9A (DNGR1); a type II transmembrane protein functioning as an endocytic receptor on BDCA31+ dendritic cells and on a subset of CD14+ CD16- monocytes.
Immunogen:
RBL-2H3 cells expressing human CLEC9A fused to an HA epitope
Isotype:
Mouse IgG2a
Purification:
The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
Supplier:
Abeomics
Type:
Antibodies
  • Manufacturer's Data Sheet:1.jpg
Figure 2 : Flow cytometry multicolor surface staining of human peripheral blood mononuclear cells stained using anti-human CD370 (8F9) PE antibody (10 µl reagent / 100 µl of peripheral whole blood) and anti-human HLA-DR (MEM-12) APC antibody (10 µl reagent / 100 µl of peripheral whole blood).
Figure 3 :Separation of human CD370 positive HLA-DR positive cells (red-filled) from CD370 negative HLA-DR negative cells (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD370 (8F9) PE antibody (10 µl reagent / 100 µl of peripheral whole blood).
Figure 3 :Separation of human CD370 positive HLA-DR positive cells (red-filled) from CD370 negative HLA-DR negative cells (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD370 (8F9) PE antibody (10 µl reagent / 100 µl of peripheral whole blood).