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Antibodies

Anti-CD370 Antibody (Clone : 8F9)

Product Sizes
0.1 mg
£570.00
30-2569-0.1MG
About this Product
SKU:
30-2569
Additional Names:
CLEC9A; DNGR1; DNGR-1; UNQ9341;C-type lectin domain containing 9A
translate.label.attr.clone:
8F9
Clonality:
Monoclonal
Extra Details:
CD370 / CLEC9A; also known as DNGR1; is a type II transmembrane glycoprotein with extracellular C-type lectin domain and intracellular ITAM-containing domain. Its expression is restricted to BDCA3+ conventional dendritic cells and to a subset of CD14+ CD16- monocytes. CD370 serves as a receptor for ubiquitous preformed acid-labile protein associated ligands that are exposed when the cell membrane is damaged; such as on necrotic cells. Its triggering by these ligands mediates recruitment and activation of the tyrosine kinase Syk and leads to their cross-presentation to the immune system.Specificity : The mouse monoclonal antibody 8F9 recognizes an extracellular epitope of CD370 / CLEC9A (DNGR1); a type II transmembrane protein functioning as an endocytic receptor on BDCA31+ dendritic cells and on a subset of CD14+ CD16- monocytes.
Format:
Purified
Immunogen:
RBL-2H3 cells expressing human CLEC9A fused to an HA epitope
Isotype:
Mouse IgG2a
Purification:
Purified by protein-A affinity chromatography
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at 2-8[o]C. Do not freeze.
Supplier:
Abeomics
Type:
Antibodies
  • Manufacturer's Data Sheet:1.jpg
Figure 2 : Flow cytometry multicolor surface staining of human myeloid cells stained using anti-human CD370 (8F9) purified antibody (concentration in sample 1;67 µg/ml; GAM FITC) and anti-human CD16 (3G8) APC antibody (10 µl reagent / 100 µl of peripheral whole blood).
Figure 3 :Separation of human CD370 positive CD16 positive dendritic cells (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD370 (8F9) purified antibody (concentration in sample 1;67 µg/ml) GAM FITC.
Figure 3 :Separation of human CD370 positive CD16 positive dendritic cells (red-filled) from neutrophil granulocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD370 (8F9) purified antibody (concentration in sample 1;67 µg/ml) GAM FITC.