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Antibodies

Anti-Human CD45 APC (Clone : 2D1)

Product Sizes
100 tests
£620.00
30-2563-100TESTS
About this Product
SKU:
30-2563
Additional Names:
LCA; T200; LY5; B220; GP180; TPC;protein tyrosine phosphatase receptor type C
translate.label.attr.clone:
2D1
Clonality:
Monoclonal
Conjugate:
APC
Extra Details:
CD45 (LCA; leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells; comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling; serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains; whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling; CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.Specificity : The mouse monoclonal antibody 2D1 reacts with an extracellular epitope of all alternative forms of human CD45 antigen (Leukocyte Common Antigen); a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin; except from erythrocytes and platelets.
Immunogen:
Human peripheral blood mononuclear cells
Isotype:
Mouse IgG1 kappa
Purification:
The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Figure 2 : Separation of human CD45 positive lymphocytes (red-filled) from human CD45 negative blood debris (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD45 (2D1) APC antibody (10 µl reagent / 100 µl of peripheral whole blood).
Figure 2 : Separation of human CD45 positive lymphocytes (red-filled) from human CD45 negative blood debris (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD45 (2D1) APC antibody (10 µl reagent / 100 µl of peripheral whole blood).