Anti-Human CD49d FITC (Clone : 9F10)
Product Sizes
100 tests
£581.00
30-2561-100TESTS
About this Product
- SKU:
- 30-2561
- Additional Names:
- ITGA4; VLA-4 alpha;integrin subunit alpha 4
- translate.label.attr.clone:
- 9F10
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- CD49d / integrin alpha 4; unlike other alpha integrins; neither contains an I-domain; nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin; and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1); but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells; and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.Specificity : The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin); a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells; monocytes; eosinophils; basophils; NK cells; and dendritic cells; but not platelets.
- Isotype:
- Mouse IgG1 kappa
- Purification:
- The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
