Anti-Human CD8 APC (Clone : LT8)
Product Sizes
100 tests
£620.00
30-2546-100TESTS
About this Product
- SKU:
- 30-2546
- Additional Names:
- p32; LEU2
- translate.label.attr.clone:
- LT8
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells; intraepithelial lymphocytes; NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8; thereby affecting the functional diversity of the TCR signaling.Specificity : The mouse monoclonal antibody LT8 recognizes an extracellular epitope of CD8; a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. This antibody blocks Leu2 binding.
- Immunogen:
- human blood lymphocytes
- Isotype:
- Mouse IgG1
- Purification:
- The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
