Anti-Mouse CD8b PE (Clone : H35-17.2)
Product Sizes
0.1 mg
£581.00
30-2543-0.1MG
About this Product
- SKU:
- 30-2543
- Additional Names:
- Ly-3; Ly-C; Lyt-3
- translate.label.attr.clone:
- H35-17.2
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells; intraepithelial lymphocytes; NK cells; macrophages; mast cells; and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8; thereby affecting the functional diversity of the TCR signaling.Specificity : The rat monoclonal antibody H35-17.2 recognizes an extracellular epitope of mouse CD8b; the 32-34 kDa beta chain of the CD8 coreceptor; expressed on cytotoxic T cells and thymocytes.
- Immunogen:
- Mouse CD8b
- Isotype:
- Rat IgG2b kappa
- Purification:
- The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
