Anti-Rat CD8b Low Endotoxin Antibody (Clone : 341)
Product Sizes
0.1 mg
£532.00
30-2542-0.1MG
About this Product
- SKU:
- 30-2542
- Additional Names:
- Ly-3; Ly-C; Lyt-3;CD8b molecule
- Clonality:
- Monoclonal
- Extra Details:
- The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells; intraepithelial lymphocytes; NK cells; macrophages; mast cells; and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8; thereby affecting the functional diversity of the TCR signaling.Specificity : The mouse monoclonal antibody 341 (also known as 34.1) recognizes rat CD8b; the 32-34 kDa beta chain of the CD8 coreceptor (extracellular epitope); expressed on T cell subsets and some other cell types; such as macrophages.
- Format:
- Low Endotoxin
- Immunogen:
- CD8 positive Wistar rat splenic T cell hybridomas
- Isotype:
- Mouse IgG1 kappa
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies
- Manufacturer's Data Sheet:download_pdf.php
