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Antibodies

Anti-Granzyme B FITC (Clone : CLB-GB11)

Product Sizes
100 tests
£757.00
30-2530-100TESTS
About this Product
SKU:
30-2530
Additional Names:
GZMB; HLP; CTLA1; SECT;granzyme B
translate.label.attr.clone:
CLB-GB11
Clonality:
Monoclonal
Conjugate:
FITC
Extra Details:
Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover; granzyme B was reported to cleave directly alpha-tubulin; leading to perturbation of microtubule networks during the induced cell death.Specificity : The mouse monoclonal antibody CLB-GB11 recognizes granzyme B; a 31 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.
Immunogen:
Human NK cell line YT-INDY-derived granzyme B
Isotype:
Mouse IgG1
Purification:
The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Figure 2 : Flow cytometry multicolor intracellular staining of human lymphocytes stained using anti-human Granzyme B (CLB-GB11) FITC antibody (4 µl reagent / 100 µl of peripheral whole blood) and anti-human CD3 (UCHT1) APC antibody (10 µl reagent / 100 µl of peripheral whole blood).
Figure 3 :Separation of human CD3 negative Granzyme B positive lymphocytes (red-filled) from CD3 negative Granzyme B negative lymphocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-human Granzyme B (CLB-GB11) FITC antibody (4 µl reagent / 100 µl of peripheral whole blood).
Figure 3 :Separation of human CD3 negative Granzyme B positive lymphocytes (red-filled) from CD3 negative Granzyme B negative lymphocytes (black-dashed) in flow cytometry analysis (intracellular staining) of human peripheral whole blood stained using anti-human Granzyme B (CLB-GB11) FITC antibody (4 µl reagent / 100 µl of peripheral whole blood).