Anti-GRAP2 PE (Clone : UW40)
Product Sizes
0.1 mg
£620.00
30-2529-0.1MG
About this Product
- SKU:
- 30-2529
- Additional Names:
- GADS; GRID; GRAP-2; GrbX;GRB2 related adaptor protein 2
- translate.label.attr.clone:
- UW40
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells; particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules; such as Vav; Nck; Itk; and ADAP; to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins; namely Gab2; HPK1 (hematopoietic progenitor kinase 1); and Cbl. Unlike similar adaptor protein Grb2; GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.Specificity : The mouse monoclonal antibody UW40 recognizes GRAP2/GADS; a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
- Immunogen:
- GST-fusion human GRAP2/GADS protein
- Isotype:
- Mouse IgG2a
- Purification:
- The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
