Anti-MICA/MICB FITC (Clone : 6D4)
Product Sizes
0.1 mg
£660.00
30-2505-0.1MG
About this Product
- SKU:
- 30-2505
- translate.label.attr.clone:
- 6D4
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- MICA and MICB glycoproteins are members of MHC class I family; closely linked to HLA-B. However; unlike HLA molecules; MICA and MICB are not associated with beta2 microglobulin and are conformationally stable in the absence of conventional MHC class I peptide ligands. Both proteins are stress-induced antigens expressed mainly in gastrointestinal epithelium; where they are recognized by V-delta1 subset of gamma/delta T cells; and also on diverse epithelial tumor cells. Binding of MICA/MICB receptor; the NKG2D; leads to cytolytic response of NK cells; Tc cells; and gamma/delta T cells. Alternative splicing results in multiple isoforms; and some of them have been associated with susceptibility to psoriasis and psoriatic arthritis. Shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma.Specificity : The mouse monoclonal antibody 6D4 recognizes a common extracellular epitope on MICA and MICB glycoproteins; transmembrane ligands of NKG2D; and is able to block NKG2D-mediated activation of NK cells and cytotoxic T cells.
- Immunogen:
- Transfected C1R cells expressing MICA
- Isotype:
- Mouse IgG2a
- Purification:
- The purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
