Anti-CD45 Monoclonal Antibody (Clone:EM-05)-PerCP Conjugated
Product Sizes
0.1 mg
£620.00
30-2443-0.1MG
About this Product
- SKU:
- 30-2443
- Additional Names:
- Ptprc||Ly-5
- translate.label.attr.clone:
- EM-05
- Clonality:
- Monoclonal
- Conjugate:
- PerCP
- Extra Details:
- CD45 (LCA; leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells; comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling; serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains; whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling; CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
- Host:
- Rat
- Immunogen:
- Murine peripheral blood leukocytes
- Isotype:
- Rat IgG
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
