Anti-CD5 Monoclonal Antibody (Clone:53-7.3)-PE Conjugated
Product Sizes
0.1 mg
£521.00
30-2368-0.1MG
About this Product
- SKU:
- 30-2368
- Additional Names:
- Cd5||Ly-1
- translate.label.attr.clone:
- 53-7.3
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- CD5 (T1) is a single-chain transmembrane glycoprotein expressed on all mature T-lymphocytes; most of thymocytes; subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization; tyrosine phosphorylation of intracellular proteins and DAG production. CD5 may serve as a dual receptor; giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals; in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.
- Host:
- Rat
- Immunogen:
- mouse thymus or spleen cells
- Isotype:
- Rat IgG2a
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
