PE Conjugated Anti-EGFR Monoclonal Antibody (Clone:EGFR1)
Product Sizes
100 tests
£660.00
30-2331-100TESTS
About this Product
- SKU:
- 30-2331
- Additional Names:
- EGFR||ERBB||ERBB1||HER1
- translate.label.attr.clone:
- EGFR1
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- The oncoprotein EGFR (epidermal growth factor receptor); also known as HER1 / ErbB1; is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis; although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
- Host:
- Mouse
- Immunogen:
- Human epidermoid carcinoma line A431
- Isotype:
- Mouse IgG2b
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
