PE-Cy7 Conjugated Anti-CD105 / Endoglin Monoclonal Antibody (Clone:MEM-226)
Product Sizes
100TESTS
£760.00
30-2196PE-Cy7-100TESTS
About this Product
- SKU:
- 30-2196PE-Cy7
- Additional Names:
- ENG||END||Endoglin||HHT1||ORW1
- translate.label.attr.clone:
- MEM-226
- Clonality:
- Monoclonal
- Conjugate:
- PE/CY7
- Extra Details:
- CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing; infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. Specificity:The antibody MEM-226 reacts with an extracellular epitope of CD105 (Endoglin); a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels); activated monocytes and tissue macrophages; stromal cells of certain tissues including bone marrow; pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
- Host:
- Mouse
- Immunogen:
- Recombinant Vaccinia virus containing the human CD105 cDNA.
- Isotype:
- Mouse IgG2a
- Purification:
- Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-cyanine 7 (PE-Cy7) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion c
- Reactivities:
- Human, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
