Anti-CD8 Monoclonal Antibody (Clone:MEM-31)-PE Conjugated
Product Sizes
100 tests
£620.00
30-2158-100TESTS
About this Product
- SKU:
- 30-2158
- Additional Names:
- T-lymphocyte differentiation antigen T8/Leu-2; CD8a; MAL
- translate.label.attr.clone:
- MEM-31
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- The CD8 T cell coreceptor (monomer approx. 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells; intraepithelial lymphocytes; NK cells and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha-beta but not alpha-alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8; thereby affecting the functional diversity of the TCR signaling.
- Host:
- Mouse
- Immunogen:
- Crude thymus membrane fraction.
- Isotype:
- Mouse IgG2a
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
