Anti-CD8b Monoclonal Antibody (Clone:341)-FITC Conjugated
Product Sizes
0.1 mg
£561.00
30-2073-0.1MG
About this Product
- SKU:
- 30-2073
- Additional Names:
- Cd8b; Cd8b1; CD8 antigen 37 kDa chain; OX-8 membrane antigen
- Clonality:
- Monoclonal
- Conjugate:
- FITC
- Extra Details:
- The CD8b (CD8 beta) subunit of CD8 T cell coreceptor is expressed in CD8 alpha/beta heterodimers on majority of MHC I-restricted conventional T cells and thymocytes and in CD8 alpha/alpha homodimers on subsets of memory T cells; intraepithelial lymphocytes; NK cells; macrophages; mast cells; and dendritic cells. Regulation of CD8 beta level on T cell surface seems to be an important mechanism to control their effector function. Assembly of CD8 alpha/beta but not alpha/alpha dimers is connected with formation or localization to the lipid rafts. Recruiting triggered TCR complexes to these membrane microdomains as well as affinity of TCR to MHC I is modulated by CD8; thereby affecting the functional diversity of the TCR signaling.
- Host:
- Mouse
- Immunogen:
- CD8 positive Wistar rat splenic T cell hybridomas
- Isotype:
- Mouse IgG1
- Reactivities:
- Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
