Anti-CD222 / IGF2 receptor / CIMPR Monoclonal Antibody (Clone:MEM-238)-Biotin Conjugated
Product Sizes
0.1 mg
£581.00
30-1873-0.1MG
About this Product
- SKU:
- 30-1873
- Additional Names:
- IGF2R||MPRI
- translate.label.attr.clone:
- MEM-238
- Clonality:
- Monoclonal
- Conjugate:
- Biotin
- Extra Details:
- CD222 (CIMPR; cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly; CD222 is crutial for internalization and degradation of insulin-like growth factor 2; thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor); plasminogen and latent TGF-beta; last but not least CD222 serves as a receptor for heparanase and even for Listeria.
- Host:
- Mouse
- Immunogen:
- Recombinant Vaccinia virus encoding CD222.
- Isotype:
- Mouse IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
