APC Conjugated Anti-Notch 1 Monoclonal Antibody (Clone:mN1A)
Product Sizes
0.1 mg
£581.00
30-1783-0.1MG
About this Product
- SKU:
- 30-1783
- Additional Names:
- NOTCH1; TAN1; Motch A; mT14; p300
- translate.label.attr.clone:
- mN1A
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- Notch 1 is a 270-300 kDa transmembrane heterodimeric protein with multiple extracellular growth factor-like repeats; and with an intracellular domain consisting of multiple different domain types. It serves as a receptor for membrane ligands; such as Delta 1; Jagged1 (CD339); and Jagged2; and regulates cell fate decisions. Upon ligand binding the transmembrane form of Notch 1 is repeatedly cleaved to provide approximately 120 kDa Notch intracellular fragment (NICD); which translocates to the nucleus and acts as a part of transcriptional complexes that alter differentiation; proliferation; and apoptosis. The highest level of Notch 1 expression is in brain; lung and thymus.
- Host:
- Mouse
- Immunogen:
- GST fusion protein containing cdc10-NCR region of mouse Notch1
- Isotype:
- Mouse IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
