APC Conjugated;Anti-CD4 Monoclonal Antibody (Clone:GK1.5)
Product Sizes
0.1 mg
£620.00
30-1753-0.1MG
About this Product
- SKU:
- 30-1753
- Additional Names:
- Cd4
- translate.label.attr.clone:
- GK1.5
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- CD4 is a single chain transmembrane glycoprotein of immunoglobulin supergene family. In its extracellular region there are 4 immunoglobulin-like domains (1 Ig-like V-type and 3 Ig-like C2-type). The intracellular region of CD4 associates with p56Lck; a Src-like protein tyrosine kinase. It was described that CD4 segregates into specific detergent-resistant T-cell membrane microdomains. CD4 binds to MHC class II molecules (by CDR2-like region in CD4 domain 1); HIV envelope protein gp120 (by CDR2-like region in CD4 domain 1) and other ligands; such as IL-16 (by to CD4 domain 3) or L-selectin. CD4 is a co-receptor involved in immune response (co-receptor activity in binding to MHC class II molecules) and HIV infection. CD4 regulates T-cell activation; T/B-cell adhesion; T-cell diferentiation; T-cell selection and signal transduction. Defects in antigen presentation (MHC class II) cause dysfunction of CD4+ T-cells and their almost complete absence in patients blood; tissue and organs (SCID immunodeficiency).
- Host:
- Rat
- Immunogen:
- Mouse CTL clone V4 cells
- Isotype:
- Rat IgG2b
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
