Anti-CD5 Monoclonal Antibody (Clone:CRIS1)-APC Conjugated
Product Sizes
100 tests
£620.00
30-1734-100TESTS
About this Product
- SKU:
- 30-1734
- Additional Names:
- CD5||LEU1
- translate.label.attr.clone:
- CRIS1
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- CD5 antigen (T1; 67 kDa) is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes; most of thymocytes; subset of B-lymphocytes and on many T-cell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains.The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization; tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70; p56lck; p59fyn; PC-PLC; etc. CD5 may serve as a dual receptor; giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals; in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.Disease relevance: CD5 is a phenotypic marker for some B cell lymphoproliferative disorders (B-CLL; Hairy cell leukemia; etc.). The CD5+ popuation is expanded in some autoimmune disorders (Rheumatoid Arthritis; etc.). Herpes virus infections induce loss of CD5 expression in the expanded CD8+ human T cells.
- Host:
- Mouse
- Immunogen:
- stimulated human leukocytes
- Isotype:
- Mouse IgG2a
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
