Anti-CD31 / PECAM-1 Monoclonal Antibody (Clone:MEM-05)-APC Conjugated
Product Sizes
100 tests
£620.00
30-1701-100TESTS
About this Product
- SKU:
- 30-1701
- Additional Names:
- PECAM1
- translate.label.attr.clone:
- MEM-05
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- CD31 (platelet endothelial cell adhesion molecule-1; PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding; which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion; transendothelial migration; angiogenesis; apoptosis; negative regulation of immunoreceptor signaling; autoimmunity; macrophage phagocytosis; IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
- Host:
- Mouse
- Immunogen:
- Leukocytes of patient suffering from LGL-type leukaemia
- Isotype:
- Mouse IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
