Anti-CD18 / Integrin beta2 subunit Monoclonal Antibody (Clone:MEM-48)-APC Conjugated
Product Sizes
100 tests
£620.00
30-1689-100TESTS
About this Product
- SKU:
- 30-1689
- Additional Names:
- ITGB2||CD18||MFI7
- translate.label.attr.clone:
- MEM-48
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- CD18; integrin beta2 subunit; forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18; LFA-1); alphaMbeta2 (CD11b/CD18; Mac-1; CR3); alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases; the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration; mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
- Host:
- Mouse
- Immunogen:
- Leukocytes of a patient suffering from a LGL-type leukemia.
- Isotype:
- Mouse IgG1
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark at 2-8[o]C. Do not freeze. Avoid prolonged exposure to light.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
