Anti-CD11a / LFA-1 alpha chain Monoclonal Antibody (Clone:MEM-25)-Low Endotoxin
Product Sizes
0.1 mg
£532.00
30-1596-0.1MG
About this Product
- SKU:
- 30-1596
- Additional Names:
- ITGAL||CD11A
- translate.label.attr.clone:
- MEM-25
- Clonality:
- Monoclonal
- Extra Details:
- CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1); the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation; which supports tight binding of LFA-1 to its ligands; the intercellular adhesion molecules ICAM-1; -2; -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement; but participates also in control of cell differentiation and proliferation and of T-cell effector functions. Blocking of LFA-1 function by specific antibodies or small molecules has become an important therapeutic approach in treatment of multiple inflammatory diseases. For example; humanized anti-LFA-1 antibody Efalizumab (Raptiva) is being used to interfere with T cell migration to sites of inflammation; binding of cholesterol-lowering drug simvastatin to CD11a allosteric site leads to immunomodulation and increase in lymphocytic cholinergic activity.
- Format:
- Low Endotoxin
- Host:
- Mouse
- Immunogen:
- Leukocytes from a pacient suffering from a LGL-type leukaemia.
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:download_pdf.php
