Anti-ARHGEF4 / ASEF1 Monoclonal Antibody (Clone:ARHGEF-08)
Product Sizes
0.1 mg
£551.00
30-1521-0.1MG
About this Product
- SKU:
- 30-1521
- Additional Names:
- ARHGEF4||KIAA1112
- translate.label.attr.clone:
- ARHGEF-08
- Clonality:
- Monoclonal
- Extra Details:
- ARHGEF4 (Rho guanine nucleotide exchange factor 4); also known as ASEF 1 (adenomatous polyposis coli - stimulated guanine nucleotide exchange factor 1) is an approximately 80 kDa cytoplasmic protein important for growth factor-mediated regulation of cell morphology and migration. Besides N-terminal adenomatous polyposis coli (APC)-binding region (ABR) it contains Dbl homology (DH); Pleckstrin homology (PH) and SH3 domains. The SH3 domain inhibits GEF activity of ARHGEF4 by intramolecular interaction with the DH domain; whereas binding of APC stimulates the GEF activity. Activated ARHGEF4 stimulates the small GTPase Cdc42; which leads to decreased cell-cell adherence and enhanced cell migration.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human ARHGEF4 (amino acids 143-271)
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
