Anti-RLTPR / CARMIL2 Monoclonal Antibody (Clone:EM-53)
Product Sizes
0.1 mg
£581.00
30-1518-0.1MG
About this Product
- SKU:
- 30-1518
- Additional Names:
- CARMIL2||LRRC16C||RLTPR
- translate.label.attr.clone:
- EM-53
- Clonality:
- Monoclonal
- Extra Details:
- RLTPR / CARMIL2 (RGD motif; leucine rich repeats; tropomodulin domain and proline-rich containing; capping protein regulator and myosin 1 linker 2); also known as LRRC16C; is a cytosolic protein; which with high affinity binds CAPZA2 (capping protein muscle actin Z-line alpha 2) and decreases CAPZA2 affinity for actin barbed ends. RLTPR / CARMIL2 increases the rate of actin filament elongation from seeds in the presence of CAPZA2; however; seems unable to nucleate filaments. Its interaction with CAPZA2 is essential for lamellipodial protrusion and cell translocation. RLTPR / CARMIL2 is crutial for T cell costimulation via CD28 and this property seems to be independent on its actin-uncapping function. The lack of functional RLTPR / CARMIL2 molecules impeded the differentiation toward Th1 and Th17 fates of both human and murine CD4+ T cells and leads to combined immunodeficiency. Expression of RLTPR / CARMIL2 was also detected in human and murine B cells; but it seems not to be involved in BCR-mediated signaling.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Murine Rltpr (amino acids 1147-1397)
- Isotype:
- Mouse IgG1
- Purification:
- Purified from hybridoma culture supernatant by protein-A affinity chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:30-1518.jpg
