PE Conjugated Anti-CD105 Monoclonal Antibody (Clone:MJ7/18)
Product Sizes
0.1 mg
£555.00
30-1515PE-0.1MG
About this Product
- SKU:
- 30-1515PE
- Additional Names:
- Eng||Edg||Endoglin
- translate.label.attr.clone:
- MJ7/18
- Clonality:
- Monoclonal
- Conjugate:
- PE
- Extra Details:
- CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing; infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels. Specificity: The rat monoclonal antibody MJ7/18 reacts with an extracellular epitope of CD105 (Endoglin); a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels); activated monocytes and tissue macrophages; stromal cells of certain tissues including bone marrow; pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow.
- Format:
- Purified
- Host:
- Rat
- Immunogen:
- Inflamed mouse skin
- Isotype:
- Rat IgG2a kappa
- Purification:
- Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Protect from prolonged exposure to light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
