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Antibodies

Anti-PCLO Monoclonal Antibody (Clone:PCLO-01)

Product Sizes
0.1 mg
£581.00
30-1500-0.1MG
About this Product
SKU:
30-1500
Additional Names:
PCLO||ACZ||KIAA0559
translate.label.attr.clone:
PCLO-01
Clonality:
Monoclonal
Extra Details:
PCLO (piccolo; also known as aczonin) is a large (more than 400 kDa) multidomain protein of the presynaptic cytomatrix in neurons; that is present in all vertebrate synapses; but is absent from invertebrates. It contains zinc finger and coiled-coil sequences; as well as N-terminal glutamine-rich sequence; and C-terminal PDZ domain followed by two C2 domains (C2A and C2B). In vitro binding and transfection experiments suggested that PCLO binds to multiple proteins including profilin and L-type calcium channels. It is involved in neurotransmitter release and insulin secretion.
Format:
Purified
Host:
Mouse
Immunogen:
Human recombinant PCLO protein
Isotype:
Mouse IgG1
Purification:
Purified by protein-A affinity chromatography
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at 2-8[o]C. Do not freeze.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
  • Manufacturer's Data Sheet:1.jpg
Fig. 1: Western blot of human REH erythroid cell line lysate (1% laurylmaltoside); non-reduced sample; immunostained by mAb PCLO-01 and goat anti-mouse IgG (H+L)-HRP conjugate. The zone evidently corresponds to a small splice variant of the PCLO protein present in this type of cell (see Uniprot database; Genome Res. 14:2121-2127(2004)); the major form (over 500 kDa) expressed in neurons is too large for analysis by Western blotting.