APC Conjugated Anti-EGFR Monoclonal Antibody (Clone:EGFR1)
Product Sizes
100 Tests
£649.00
30-1484AC-100TESTS
About this Product
- SKU:
- 30-1484AC
- Additional Names:
- EGFR||ERBB||ERBB1||HER1
- translate.label.attr.clone:
- EGFR1
- Clonality:
- Monoclonal
- Conjugate:
- APC
- Extra Details:
- The oncoprotein EGFR (epidermal growth factor receptor); also known as HER1 / ErbB1; is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis; although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Human epidermoid carcinoma line A431
- Isotype:
- Mouse IgG2b
- Purification:
- Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C protected from light. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:30-1484AC 1.jpeg
