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Antibodies

Anti-EGFR Monoclonal Antibody (Clone:EGFR1) Purified

Product Sizes
0.1 mg
£570.00
30-1484-0.1MG
About this Product
SKU:
30-1484
Additional Names:
EGFR||ERBB||ERBB1||HER1
translate.label.attr.clone:
EGFR1
Clonality:
Monoclonal
Extra Details:
The oncoprotein EGFR (epidermal growth factor receptor); also known as HER1 / ErbB1; is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis; although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.
Format:
Purified
Host:
Mouse
Immunogen:
Human epidermoid carcinoma line A431
Isotype:
Mouse IgG2b
Purification:
Purified by protein-A affinity chromatography
Reactivities:
Human
Shipping Conditions:
Blue Ice
Storage Conditions:
Store at 2-8[o]C. Do not freeze.
Supplier:
Abeomics
Type:
Antibodies:Monoclonal Antibody
Figure 2: Separation of A-431 cells (red-filled) from SP2 cells (black-dashed) in flow cytometry analysis (surface staining) of cell lines stained using anti-EGFR (EGFR1) purified antibody GAM APC.
Figure 2: Separation of A-431 cells (red-filled) from SP2 cells (black-dashed) in flow cytometry analysis (surface staining) of cell lines stained using anti-EGFR (EGFR1) purified antibody GAM APC.