Anti-CD19 Monoclonal Antibody (Clone:4G7 )
Product Sizes
0.1 mg
£532.00
30-1469-0.1MG
About this Product
- SKU:
- 30-1469
- Additional Names:
- CD19; B4; Leu-12; CVID3
- translate.label.attr.clone:
- 4G7
- Clonality:
- Monoclonal
- Extra Details:
- Specificity: The mouse monoclonal antibody 4G7 recognizes an extracellular epitope of human CD19. CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2); CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor); this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR; CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia; whereas CD19 overexpression causes B cell hyperactivity.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Human CCL (chronic lymphocytic leukemia) cells
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
