Anti-beta-Catenin Monoclonal Antibody (Clone:EM-22)
Product Sizes
0.1 mg
£581.00
30-1388-0.1MG
About this Product
- SKU:
- 30-1388
- Additional Names:
- Beta-catenin; CTNNB
- translate.label.attr.clone:
- EM-22
- Clonality:
- Monoclonal
- Extra Details:
- Beta-catenin is a multifunctional protein involved both in cell adhesion and in activation of transcription. Calcium-dependent intercellular adhesion transmembrane glycoprotein E-cadherin interacts by its cytoplasmic domain with reciprocally bound alpha; beta and gamma catenin. Beta-catenin links this complex through alpha-actinin to the cytoskeleton. Functional cadherin-catenin system is important for invasiveness of tumour cells. Beta-catenin level in cytoplasm is controlled by glycogen synthase kinase-3 beta. When activity of this kinase is blocked (e.g. by excessive stimulation of Wnt signaling pathway); hypophosphorylated stable form of beta-catenin accumulates in the cytoplasm; translocates to the nucleus and activates transcription of genes including those that are involved in cell cycle control. As a result; cell division and neoplastic transformation are promoted.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant human beta-catenin
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
