Anti-GCPII / PSMA Monoclonal Antibody (Clone:GCP-04)
Product Sizes
0.1 mg
£591.00
30-1370-0.1MG
About this Product
- SKU:
- 30-1370
- Additional Names:
- FOLH1||FOLH||NAALAD1||PSM||PSMA||GIG27
- translate.label.attr.clone:
- GCP-04
- Clonality:
- Monoclonal
- Extra Details:
- Glutamate carboxypeptidase II (GCPII); also known as N-acetyl-alpha-linked acidic dipeptidase I (NAALADase I); folate hydrolase (FOLH1); and prostate-specific membrane antigen (PSMA); is an approximately 95-110 kDa type II transmembrane glycoprotein expressed in various tissues. In nervous system GCPII cleaves abundant N-acetylaspartylglutamate; which is released from neurons in a calcium-dependent manner; to N-acetylaspartate and glutamate. As immoderate glutamate concentration is neurotoxic; GCPII contributes to pathological conditions regarding e.g. Alzheimer´s disease; Huntington´s disease; epilepsy; schizophrenia; stroke or neuropathic pain and appears to be an interesting therapeutic target. In jejunum GCPII hydrolyzes pteroylpoly-gamma-glutamate to folate and glutamate; enabling folate to be absorbed by gastrointestinal tract. GCPII; which is present in a number of tissues at low levels; is overexpressed in neovasculature of most solid tumours and is a target enzyme for diagnosis and treatment of prostate cancer. Normal human prostate express more mRNA coding for a cytosolic GCPII form truncated at the N-terminus (PSM´) than mRNA for membrane-bound GCPII; and this ratio is reversed upon malignant transformation.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Recombinant fragment of human GCPII (amino acids 44-750) produced in S2 cells
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
