Anti-p53 (Phospho-Ser392) Monoclonal Antibody (Clone:FP3.2 [FPS392])
Product Sizes
0.1 mg
£581.00
30-1325-0.1MG
About this Product
- SKU:
- 30-1325
- Additional Names:
- TP53||P53
- translate.label.attr.clone:
- FP3.2 [FPS392]
- Clonality:
- Monoclonal
- Extra Details:
- The tumour suppressor protein p53 is a key element of intracellular anticancer protection. It mediates cell cycle arrest or apoptosis in response to DNA damage or to starvation for pyrimidine nukleotides. It is up-regulated in response to these stress signals and stimulated to activate transcription of specific genes; resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest; or proteins that trigger apoptosis; such as Bcl-2. The structure of p53 comprises N-terminal transactivation domain; central DNA-binding domain; oligomerisation domain; and C-terminal regulatory domain. There are various phosphorylation sites on p53; of which the phosphorylation at Ser15 is important for p53 activation and stabilization.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- KLH-conjugated phosphopeptide RHKKLMFKTEGPDS[P]D; corresponding to amino acids 378-393 of human p53.
- Isotype:
- Mouse IgG1
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
