Anti-CD30 / Ki-1 Monoclonal Antibody (Clone:MEM-268) Alexa Fluor 647
Product Sizes
100 tests
£639.00
30-1315-AF647-100TESTS
About this Product
- SKU:
- 30-1315-AF647
- Additional Names:
- TNFRSF8||CD30||D1S166E
- translate.label.attr.clone:
- MEM-268
- Clonality:
- Monoclonal
- Extra Details:
- CD30 is a type I transmembrane glycoprotein of the TNF receptor superfamily. CD30 was originally identified as a cell surface antigen of Hodgkins and Reed-Sternberg cells using monoclonal antibody Ki-1. The ligand for CD30 is CD30L (CD153). The binding of CD30 to CD30L mediates pleiotropic effects including cell proliferation; activation; differentiation; and apoptotic cell death. CD30 has a critical role in the pathophysiology of Hodgkin's disease and other CD30+ lymphomas. CD30 acts as a costimulatory molecule in thymic negative selection. In addition to its expression on Hodgkin's and Reed-Sternberg cells; CD30 is also found in some non-Hodgkin's lymphomas (including Burkitt's lymphomas); virus-infected T and B cells; and on normal T and B cells after activation. In T cells; CD30 expression is present on a subset of T cells that produce Th2-type cytokines and on CD4+/CD8+ thymocytes that co-express CD45RO and the IL4 receptor. Soluble form of CD30 (sCD30) serves as a marker reflecting Th2 immune response.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Expression vector containing CD30 cDNA (booster suspension of THP-1 cell line)
- Isotype:
- Mouse IgG 2a; kappa
- Purification:
- Purified by protein-A affinity chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:30-1315-AF.jpg
