Anti-Neurofilament heavy protein Monoclonal Antibody (Clone:NF-05)
Product Sizes
0.1 mg
£561.00
30-1304-0.1MG
About this Product
- SKU:
- 30-1304
- Additional Names:
- NEFH||KIAA0845||NFH
- translate.label.attr.clone:
- NF-05
- Clonality:
- Monoclonal
- Extra Details:
- Neurofilaments (NFs) are a type of intermediate filaments (IF) expressed almost exclusively in neuronal cells; and in those cells most prominently in large axons. NFs in most vertebrates are composed of three different polypeptide chains with different molecular weights - neurofilament heavy protein (NF-H); medium (NF-M) and light protein (NF-L); which share sequence and structural similarity in a coiled-coil core domain; but differ in the length and sequence of their N-termini and more dramatically of their C-termini which in the case of NF-M and NF-H form the flexible extensions that link NFs to each other and to other elements in the cytoplasm. The protein segment on the C-terminal side of the human NF-H rod is uniquely long (more than 600 amino acids) compared to other IF proteins and is highly charged (> 24 % Glu; > 25 % Lys); rich in proline (> 12 %) and improverished in cysteine; methionine and aromatic amino acids. Its most remarkable feature is a repetitive sequence that covers more than half its lenght and includes the sekvence motif Lys-Ser-Pro (KSP) greater than 40 times. Plasma neurofilament heavy chain level has been proposed as a marker of axonal injury and clinical use of its degeneration and loss has been suggested as a biomarker of several neurodegenerative diseases.
- Format:
- Purified
- Host:
- Mouse
- Immunogen:
- Pig brain neurofilament protein-enriched fraction after depolymerization of microtubules
- Isotype:
- Mouse IgG1
- Purification:
- Purified by precipitation and chromatography
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 2-8[o]C. Do not freeze.
- Supplier:
- Abeomics
- Type:
- Antibodies:Monoclonal Antibody
- Manufacturer's Data Sheet:1.jpg
